On the other hand, the most common eosinophilic renal tumors (oncocytoma, eosinophilic variant of chromophobe renal cell carcinoma, and oncocytic papillary renal cell carcinoma) are considered negative for cathepsin K. However, a recent study describes the immunohistochemical expression of cathepsin K in a small series of oncocytoma (13 cases) and chromophobe renal cell carcinoma (13 cases) [69]. The gene discussed is CTSK; the disease is chromophobe renal cell carcinoma.