CTSK and adenocarcinoma: Diagnostically, the utility of the immunoexpression of cathepsin K has been limited to large series (overall 726) of adenocarcinomas of various organs, reported as single cases with focal labeling in the adrenal cortical carcinomas, urothelial carcinomas, esophageal adenocarcinomas, ovarian serous carcinomas, and pancreatic adenocarcinomas [28].