In a previous study, CDKN2A PV carriers were reported to have inferior MSS as compared with melanoma cases with no CDKN2A mutations (hazard ratio [HR] = 2.50, 95% confidence interval [CI] = 1.49 to 4.21) that was independent of stage, age and sex, and not associated with the diagnosis of subsequent primary melanomas or other tumors [2]. The gene discussed is CDKN2A; the disease is melanoma.