Inherited pathogenic variants (hereafter named PVs or mutations) in the CDKN2A tumor suppressor gene, which encodes for the cell cycle inhibitors p16ink4A and p14ARF, constitute the main risk factor for individuals with an inherited predisposition to melanoma, who are at increased risk of developing multiple melanomas and other tumors, in particular pancreatic cancer [1]. The gene discussed is CDKN2A; the disease is pancreatic neoplasm.