Contrary to the results from the 50-weeks-old HCC-bearing condition, the plasma levels of ALT (Figure 3B) and HMGB1 (Figure 3C) were higher in the short-term DEN-injured Pgrmc1-null mice compared with WT, indicating the exacerbation of hepatic injury in Pgrmc1-null mice. Here, HMGB1 is linked to hepatocellular carcinoma.