Despite the conflicting roles of Pgrmc1 in hepatocytes and macrophages, Pgrmc1-null mice with Pgrmc1 deficiency in both hepatocytes and macrophages showed suppressed HCC formation, which is in accordance with the phenotypes seen in the aforementioned study by Lanaya et al. on EGFR [71]. This evidence concerns the gene EGFR and hepatocellular carcinoma.