NF-κB signaling is a major contributor that links inflammation to HCC [65]; moreover, considering its potential relevance with Pgrmc1 in lung adenocarcinoma [66] and breast cancer [38], further targeted studies are needed in order to determine how Pgrmc1 modulates the NF-κB complex in other pathological settings. This evidence concerns the gene PGRMC1 and lung adenocarcinoma.