In contrast to SCGB3A1, the functional role of the endothelial NOSTRIN in cancer has not been fully described, although, in pancreatic cancer, NOSTRIN has been identified as a protein that binds to the endothelial nitric oxide synthase (eNOS) and manipulates its intracellular efficiency, reducing nitric oxide (NO) generation, which directly suppresses the tumor’s migratory and invasive properties [59]. This evidence concerns the gene NOSTRIN and familial pancreatic carcinoma.