Concurrently, the serine/cysteine protease inhibitor SERPINB3, which is directly manipulated by SERPINB4, is modulated by hypoxia through the hypoxia-inducible factor-2α (HIF-2α), and has been recently proven to be upregulated in human hepatoblastoma [79,80]. This evidence concerns the gene SERPINB3 and hepatoblastoma.