To complete the failure of mitochondrial homeostasis, there is also evidence of defective mitochondrial biogenesis: Both in AD’s patients’ brain, AD cellular models, and APP and tau mice models of AD, reduced levels of mRNA encoding critical players in mitochondrial biogenesis (such as PGC1α, Nrf-1, Nrf-2, and TFAM) have been found [350,351,352]. The gene discussed is APP; the disease is Alzheimer disease.