Much evidence points to exosome-mediated clearance of Aβ aggregates and p-tau; however, as an opposite way as it happens in pancreatic β-cells, it seems that exosome detoxification of harmful proteins in AD contributes to the pathological spreading of the disease, as it is proved that exosome secretion inhibition leads to improving brain degeneration [407,408,409,410]. This evidence concerns the gene MAPT and Alzheimer disease.