In addition, high-grade endometrioid carcinomas are molecularly heterogeneous: in one study, 36.2% were classified as dMMR, 12.9% POLE mutated, 20.7% TP53 mutated, and 30.2% “low copy number” (pMMR, POLE and TP53 unmutated). Here, POLE is linked to endometrioid adenocarcinoma.