Consistent with the downregulation observed in plasma samples from upgrading patients, it was reported that miR-199a-5p is under-expressed in PCa clinical specimens and acts as an oncosuppressor, since its reconstitution in PCa models decreased cell proliferation, motility and tumor angiogenesis and increased apoptosis by directly targeting HIF-1α [33]. Here, HIF1A is linked to posterior cortical atrophy.