However, the prevalence of the MSI-H/dMMR phenotype in PDAC has been reported to be only 1~2% [25], but intriguingly, the MSI-H/dMMR phenotype was found to be strongly correlated with a high tumor mutational burden (TMB) and a wild-type KRAS and p53 molecular background [66]. This evidence concerns the gene KRAS and neoplasm.