TAFAZZIN and pancreatitis: Functionally, YAP-TAZ activation was demonstrated to be required for pancreatic carcinogenesis in mice carrying the KRASG12D mutation: YAP and TAZ protein levels were upregulated in each stage of PDAC pathogenesis, including pancreatitis, acinar-to-ductal metaplasia (ADM) and pancreatic intraepithelial neoplasia (PanIN), and double knockout of Yap and Taz genes significantly mitigated KRASG12D mutation-induced ADM and PanIN lesions [12].