NFE2L2 and neoplasm: Analyzing the viability of tumor cells either transfected with a scRNA or siRNA against Nrf2, revealed that hLcn-2 protects against cell death in the presence or absence of Nrf2. Interestingly, when co-stimulating tumor cells with hLcn-2 and the antioxidant NAC prior to adding erastin, protection was lost (Figure 3H).