JAK2 and cancer: In a study on SMMC-7721 and HepG2 cells, miR-196 was found to attenuate the transcriptional activity of SOCS2 factor, thereby increasing the phosphorylation of Janus kinase 2 (JAK2) and Signal Transducer and Activator of Transcription 5A (STAT5) proteins, which play a vital role in lipid metabolism and cancer development in the liver [134,135].