EGFR and cancer: In their study, Xiong and colleagues showed that exosomal miR-490, released by mast cells, is efficiently internalized by HepG2, where it reduced the activity of epidermal growth factor receptor (EGFR)/protein kinase B (PKB)/ extracellular-signal-regulated kinase1/2 (ERK1/2) pathways, thus inhibiting the migration of cancer cells (Figure 2).