Subsequent experiments showed that miR-196 was able to promote G1-S transition, and thus HCC cell proliferation, by inhibiting Forkhead Box O1 (FOXO1) [50], which is a potent transcriptional activator of genes involved in cell cycle arrest, apoptosis, DNA repair, and hypoxia responsiveness [87]. This evidence concerns the gene FOXO1 and hepatocellular carcinoma.