In a recent meta-analysis, enteral supplementation of lactoferrin did not reduce the incidence of NEC (RR 0.90, 95% CI 0.69–1.17), whereas concomitant administration of lactoferrin and probiotics did result in a statistically significant reduction of NEC incidence (RR 0.04, 95% CI 0.00–0.62); however, these results need to interpreted with caution due to (very) low certainty of evidence [226,251]. Here, LTF is linked to necrotizing enterocolitis.