Endotoxemia (plasma) ↓ [75]Intestinal permeability (functional orogastric FITC-dextran assay) ↓ [116]Small intestinal internalization of claudin-4 in enterocyte cytoplasm (protein) ↓ [116]Small intestinal claudin-4 expression in TJ complex (protein) ↑ [116]Small intestinal occludin expression in TJ complex (protein) ↑ [116]Small intestinal co-fractioning of claudins-2 and -4 and caveolin 1 (protein) ↑ [116]intestinal permeability (functional orogastric FITC-dextran assay) ↓ [116]. The gene discussed is CLDN4; the disease is serum lipopolysaccharide activity.