Enrichment of enteral nutrition with hyaluronan 35 kD, a glycosaminoglycan present in human milk, reduced plasma concentrations of the pro-inflammatory cytokines TNFα, C-X-C motif chemokine 1 (CXCL1), interleukin 12 p70 (L12p70), IL6 and in the high dosage group also IFNΥ in a murine NEC model [94]. The gene discussed is CXCL1; the disease is necrotizing enterocolitis.