IL13 and Alzheimer disease: Dysregulation of antioxidant mechanisms contributes to oxidative stress, which is caused by an imbalance between ROS generation and activity of the antioxidant defense system [38,39,40], and reportedly, excessive oxidative stress is a major etiological factor of AD because it induces inflammatory genes such as IL-4, IL-13, and COX-2 [41,42,43,44].