HSPB1 and amyotrophic lateral sclerosis: This increase in Hsp25 expression in spinal cord samples of SOD1 G93A mice correlated with a significant increase in GFAP levels (p = 0.0251; Figure 5c), reflecting the well-characterised astrogliosis that is known to occur in the SOD1 G93A model of ALS [45,46,47].