ASAH1 and myocardial infarction: For example, Hadas et al. (2020) [56] used a new genetic tool called modified mRNA (modRNA) during myocardial infarction to increase the acid ceramidase (AC) enzyme, which increases S1P production, and found that the infarct area was reduced via decreasing cardiomyocytes’ cell death and infiltrated neutrophils.