Mera et al. (2014) [69] found that CPT1A overexpression in the ventromedial hypothalamus contributes to an obese phenotype, characterized by hyperphagia and, consequently, overweight, insulin resistance, glucose intolerance, and hyperglycemia, and led to higher levels of ceramides and sphingolipids, accompanied by increased mitochondrial reactive oxygen species, demonstrating an association between mitochondrial function and ceramide levels. This evidence concerns the gene CPT1A and Insulin resistance.