By comparison, CerS2 deficiency or insufficiency led to susceptibility to diet-induced steatohepatitis and insulin resistance, glucose intolerance, and increased C16 ceramide, suggesting that the altered sphingolipid acyl chain length directly affects insulin signaling, because it was observed as a compensatory effect for the decline in very-long-chain ceramide production by CerS2 [42,43]. This evidence concerns the gene CERS2 and Insulin resistance.