DDHD2 and hepatocellular carcinoma: We used a well-established human hepatoma cell model (HepG2) owning to the fact that these cells contain major lipid metabolizing enzymes such as triglyceride lipase or 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase (HMG-CoA reductase) [50], which validate that cell line as a proper model for steatotic phenotype studies.