MTOR and metabolic disease: These circadian anabolic and catabolic fluxes, specific to healthy people, are disturbed by aging, physical inactivity, over-nutrition and metabolic diseases leading to the idea that improvements in metabolic flow through either intermittent fasting, increased activity, caloric restriction or pharmacological compounds able of mimicking the physiology of intermittent fasting/exercise/caloric restriction on mTOR may play a critical role in AD progression.