In contrast, dipeptidyl peptidase-4 (DPP-4) inhibitors, metformin, SGLT2 inhibitors and glucagon-like peptide-1 (GLP1) agonists showed benefit, with metformin barely reaching significance, whereas both SGLT2 inhibitors and GLP1 agonists use displayed a 42% decrease in dementia risk [76]. This evidence concerns the gene SLC5A2 and dementia.