Analyzing the changes of mTOR signaling in AD transgenic mouse models, Lafay-Chebassier et al. [126] reported lower mTOR signaling and an important alteration of mTOR phosphorylation in the cerebellum of 12-month-old APP/PS1 mice than controls, contradicting a previous study that revealed hyperactive mTOR signaling in 9-month-old APP/PS1 mice. The gene discussed is PSEN1; the disease is Alzheimer disease.