MTOR and obesity due to melanocortin 4 receptor deficiency: The target of mTOR is a protein kinase with an essential role in controlling protein synthesis, cellular functions and autophagic regulation, as the disorder of this major regulator is associated with the pathogenesis of various human diseases such as AD by Aβ deposition, deterioration of the metabolic state of the cell with the onset of diabetes and obesity, the inactivation of mTOR signaling being initiated in the early stages of AD [107].