In diabetes, insulin resistance causes mitochondrial dysfunction, triggering inflammatory response with increased levels of cytokines such as interleukin (Il)-1β, Il-6, Il-8, tumor necrosis factor-alpha (TNF-α), alpha-1-antichymotrypsin (ACT) and C-reactive protein (CRP), the same mechanism being triggered in AD [65]. The gene discussed is SERPINA3; the disease is Alzheimer disease.