Notably, SphK1 was found upregulated in many different cancers, such as kidney cancer, prostate cancer, liver cancer, colorectal cancer, gastric cancer, uterine cancer, ovarian cancer, lung cancer, breast cancer, lymphoma, glioblastoma, small bowel cancer, and myeloid leukemia [32,33,34,35]. The gene discussed is SPHK1; the disease is cancer.