CXCL8 and pulmonary edema: For example, intravenous immunoglobulin (IVIG) could reduce the effects of cytokine storms by suppressing inflammatory cytokines IFN-α, IL-6, IL-10, and IL-13, as well as chemokine IL-8; however, the IVIG treatment was unable to completely reduce deaths in patients with pulmonary edema [22].