By the combination of lenalidomide with rituximab, restoration of appropriate F-actin immune synapse formation was confirmed by confocal images of clinical samples obtained from LN biopsies conjugated with circulating tumor B cells obtained from patients with leukemic state of FL, accompanied with polarized expression of granzyme B at CD8+ T cell contact sites and synapses with FL B cell and with tyrosine phosphorylated proteins in CD4+ T cells [98]. The gene discussed is CD4; the disease is neoplasm.