The previous study indicated that FL cells having cancer stem cell-like activities interacted with FDCs in a CXCL12/CXCR4 dependent manner, including resistance to cyclophosphamide or doxorubicin, in vitro and in NOD/Scid mice and that a specific CXCL12/CXCR4 inhibitor exhibited tumor growth [46]. This evidence concerns the gene CXCR4 and neoplasm.