BDNF and major depressive disorder: It was reported that: (i) age negatively correlates with total BDNF levels [28], (ii) men exhibit higher levels of BDNF compared with women in a sample including patients with depression and healthy controls [29], and (iii) antipsychotics may increase BDNF levels in patients with schizophrenia [30] in a dose-dependent manner with clozapine but not with first generation antipsychotics [49].