It has been shown in familial hemiplegic migraine 2 (FHM2), a rare subtype of migraine with aura, that mutations in the expression of Atp1a2 cause ‘loss of function’ of the Na+/K+ ATPase pump in astrocytes, therefore affecting glutamate clearance [75]. Here, ATP1A2 is linked to migraine, familial hemiplegic, 2.