The neuron–glia communication via gap junctions within the TG from in vitro studies provides evidence that neuronal calcitonin gene-related peptide (CGRP), a key neuropeptide that is released during migraine attacks and a target for newly approved migraine therapeutics, could cause the activation of the adjacent SGCs to release cytokines and chemokines [36,66,67]. This evidence concerns the gene NPS and migraine disorder.