Postmortem examinations revealed that the cortical expression of astrocytes, glutamate type II, aquaporin-4, S100B, glutaminase, GLT-1, thrombospondin, GFAP, and glutamine synthetase was significantly reduced in the brains of patients with schizophrenia [72,73], supporting the possibility of astrocyte-involved glutamatergic dyshomeostasis in these patients. Here, S100B is linked to schizophrenia.