PEDF and the PEDF peptides 17-mer and 17-mer[H105A] protect photoreceptors from damage in the rd1 and rd10 mouse models of retinal degeneration [29,34], in the Mitf knockout mouse model of microphtalmia [38], and a focal light-emitting diode (LED)-induced phototoxicity mouse model [39]. Here, PDE6B is linked to retinal degeneration.