Given the clear impact of PtpB on the transcription of specific virulence determinants shown here, its impact on S. aureus to cause disease in mice [8], and the fact that several low molecular weight protein tyrosine phosphatase inhibitors are currently in development to combat diseases such as cancer, diabetes/obesity, and bacterial infections [41,42,43,44,45], PtpB might constitute an additional interesting target for drug development against this notorious human nosocomial pathogen. Here, PTPRB is linked to bacterial infectious disease.