PGP and cancer: However, its use is limited due to both the toxicity that Dox can induce and more particularly, cardiotoxicity (i.e., cardiomyopathy, congestive heart failure) and acute myelotoxicity [14,15], but also its lack of action on cancer cells following its efflux by the overexpression of carrier ABC, such as the P-gp protein in various cancer models [45,46,47].