S100A4 and neoplasm: During this process, the cells lose essential epithelial proteins (such as E-cadherin, claudins, cytokeratin, occludins, mucin-1, desmoplakin, and γ-catenin) while express mesenchymal phenotype characteristics with Vimentin, N-cadherin, fibronectin, fibroblast-specific protein 1 (FSP-1), Vitronectin, and smooth-muscle actin which cause immunosuppression and enhance tumor dissemination and migration [11].