PLCA result from irreversible damage to the epithelial stem cells (eSCs) of the hair follicle (HF) due to (1) eHFSC apoptosis, (2) pathological epithelial-mesenchymal transition (EMT), (3) collapse of bulge immune privilege (IP) and (4) interferon-gamma-dominated Th1-type chronic inflammatory response [5,6,7,8]. Here, IFNG is linked to hydrops fetalis.