Probing our hypothesis on the role of Cav1 in the development of FFA and other PLCAs and the importance of downregulating it to strengthen and/or restore IP in the bulge of human HFs (Figure 1) may not only introduce a new pathomechanism, but could also invite a promising and innovative treatment strategy for these debilitating, irreversible hair loss disorders. The gene discussed is CAV1; the disease is Hand-foot syndrome.