Interestingly, lesional FFA HFs show cells within the bulge epithelium that are abnormally positive for the EMT markers (Snail1, Snail2, Zeb1 and TWIST1) [46], mesenchymal markers (vimentin and fibronectin) and a cadherin switch (downregulation of the epithelial cell–cell adhesion marker E-cadherin [8] and upregulation of the N-cadherin) [47,48]. This evidence concerns the gene CDH1 and Hand-foot syndrome.