These include: (1) an inducible Cav1 knockout mouse model under the control of the K15 promoter to specifically ablate Cav1 in mouse eHFSCs; (2) full-length human HF organ culture in which HF IP collapse and pathological EMT can be experimentally induced in healthy eHFSCs [8,18] in the presence or absence of Cav1-modulatory agents (incl. The gene discussed is KRT15; the disease is hydrops fetalis.