CAV1 and Hand-foot syndrome: Cav1 siRNA); (3) organ culture of lesional FFA skin biopsies obtained that demonstrate trichoscopic FFA activity (such as peripilar casts) [7] in the presence or absence of Cav1 inhibitors (e.g., cyclodextrin or Sandalore® (synthetic odorant that we have recently observed to decrease Cav1 expression in the epithelium of healthy human scalp HFs after 6 days of treatment (Figure 2), statins (Figure 5) and siRNA).