Considering that Substance P and IFN-γ have been previously demonstrated to be upregulators of MHC-I and to rapidly induce HF-IP collapse [73,74], this further substantiates our hypothesis that downregulation of Cav1 may be an alternative approach to inhibit collapse HF immune privilege and thus be a potential avenue for treatment of FFA. This evidence concerns the gene IFNG and hydrops fetalis.