TGFB1 and Hand-foot syndrome: We have also demonstrated that a defined cocktail of four well-known EMT-promoting agents (i.e., IFN-γ, TGF-β1, EGF, and a E-cadherin-inhibiting peptide) [6,8] is sufficient enough to induce pathological EMT and reduce both expression of K15, as well as the number of K15+ cells in the bulge of healthy, human scalp HFs ex vivo [18], recapitulating exactly what is seen in lesional LPP and FFA HFs [6,7,8,18] (Figure 1a).