SIRT1 and endothelial dysfunction: MiR-34 downregulates SIRT1, causing hyperglycemia-induced vascular cell senescence [65]; miR-204 promotes endothelial dysfunction and vascular ER stress [88]; and miR-106b overexpression increases the oxidative stress induced by high glucose levels in NIT-1 cells, a mouse pancreatic β-cell line [66].