The activation of these pathways due to excessive production of ROS and prolonged hyperglycemia contributes to the inhibition of glyceraldehyde-3-phosphate dehydrogenase (GAPDH) and, in turn, to the accumulation of specific precursors of the glycolytic pathway, such as fructose-6-phosphate or glyceraldehyde-3-phosphate. Here, GAPDH is linked to Hyperglycemia.