Typically, SOCE activity is mediated by the interaction of STIM1 and Orai1; however, some studies reported STIM1 interaction with other partners including TRP channels and Orai1 with the secretory pathway Ca2+ ATPase SPCA2 to elicit constitutive SOCE and enhance the carcinogenesis process in human breast cancer [71,72]. This evidence concerns the gene ORAI1 and breast carcinoma.