We previously reported that KPNB1 inhibition resulted in not only radiosensitization but also attenuation of radiation-increased PD-L1 expression in HNSCC cells [13], indicating that co-treatment with KPNB1 blockage and ionizing radiation is a promising strategy for HNSCC therapy. Here, KPNB1 is linked to head and neck squamous cell carcinoma.