In our study, we found significantly higher serum levels of MMP-2 and MMP-9 in the T2D patients compared to controls (Table 1) and a positive correlation between MMP-2 and ACIVAbs IgM in the T2D group, showing the linear relationship between MMP-2 levels and vascular CIV turnover (Figure 1C). This evidence concerns the gene CD40LG and type 2 diabetes mellitus.