HIF1A and hereditary clear cell renal cell carcinoma: KEGG pathway analyses identified overrepresentation of genes associated with the HIF-1 signaling pathway (KEGG:04066; P = 4.15 × 10−7), fructose and mannose metabolism (KEGG:00051; P = 8.90 × 10−4) and renal cell carcinoma (KEGG:05211; P = 3.345 × 10−2) in the up-regulated genes (Table 2).