One of these proteins can be dentine matrix protein 1 (DMP-1) expressed by osteocytes, which can be used to distinguish between DMP-1 positive osteosarcoma and osteoblastoma from DMP-1 negative: CHSs, enchondromas, osteochondromas, melanoma, and some carcinomas, like for example, adenocarcinomas or renal cell carcinoma [35]. The gene discussed is DMP1; the disease is osteosarcoma.