It is interesting to note that B cells and monocyte/macrophages are two subtypes notoriously not depleted during HIV-1 infection, both in NP and LTNP. In monocyte/macrophages, known as important reservoirs for the life cycle of the virus [29], the expression of TRIM5α is coupled to the expression of other autophagy-related proteins, such as BECN1, LC3s/GABARAPs, SQSTM1, HDAC6, and IRGM [8], thus emphasizing the strategic role of autophagy in the survival of these cells and viral replication during HIV-1-infection [30]. This evidence concerns the gene IRGM and HIV-1 infection.