Interestingly, grade I astrocytomas were found to be positive with APBs but lacked long and heterogeneous telomeres as measured by TRF, which prompted Slatter and colleagues to classify grade I astrocytomas in their study as “telomere-associated promyelocytic leukemia (PML) bodies” positive and yet ALT negative [95]. This evidence concerns the gene PML and astrocytoma (excluding glioblastoma).