Although not addressed in our study, it is possible that upon entering the interstitial space, the ability of lamin A/C rich tumor cells to enzymatically degrade glycoprotein and proteoglycan components of collagenous barriers [63] is more critical for their interstitial motility than the mechanical restrictions imposed by the stiffness of their lamin A/C rich nuclei. This evidence concerns the gene ART4 and neoplasm.