In vitro studies with the use of rat inferior vena cava model of DVT and human umbilical vein endothelial cells (HUVECs) culture showed an association between increased IL-18 expression and DVT occurrence through an increase in vWF and p-selectin expression, as well as a decrease in tissue plasminogen activator (tPA) [56]. This evidence concerns the gene IL18 and deep vein thrombosis.