Indeed, different studies have reported that ectopic miR-34a expression induces apoptosis, cell cycle arrest, and senescence, as well as inhibiting cell growth in PCa cells through repression of different targets, including SIRT1 [71], Wnt1 [72], c-Myc [73], and STMN1 [74] (Table 1). This evidence concerns the gene SIRT1 and posterior cortical atrophy.