Alterations, mutations, and aberrant expression of genes strictly involved in the DDR system and checkpoints (i.e., p53/MDM2, ATM/ATR) and programmed cell death signaling (i.e., PTEN/Akt, Bax/Bcl-2, PARP-1) have been frequently reported in PCa and associated with adverse outcome to radiotherapy [32,33,34]. The gene discussed is BCL2; the disease is posterior cortical atrophy.