In line with its reported oncogenic role, Guan et al. found that miR-21 was highly expressed in PCa cells and its overexpression promoted PCa cell proliferation, migration, invasion, and resistance to apoptosis by directly targeting KLF5 and consequent upregulation of GSK3B and activation of the AKT signaling pathway [75] (Table 1). The gene discussed is AKT1; the disease is posterior cortical atrophy.