TGFB1 and non-small cell lung carcinoma: Upregulation of several transcription and growth factors such as TGFβ, Snail, twist, deca-pentaplegic homolog (Smad) and cyclinD1, as well as hypoxia-inducible factors (e.g., HIF-1α) induce EMT in NSCLC cells via activation of the Notch signaling pathway [47,48].