The effect of luteolin is induced via down-regulating expression of the focal adhesion kinase (FAK) and non-receptor tyrosine kinase (Src) downstream pathways, including the Ras homolog gene family member A (RhoA), cell division control protein 42 (Cdc42) and Ras-related C3 botulinum toxin substrate 1 (Rac1) [27].The natural flavone luteolin has been reported to suppress mast cells (MCs) that mature in human tissues and are implicated in asthma. The gene discussed is RAC1; the disease is asthma.