TP53 and lung cancer: The main mechanisms include (1) suppression of receptor tyrosine kinase (RTK), which is able to mediate activation of cellular signaling pathways, leading to the promotion of lung cancer tumor growth, (2) suppression of proliferation in lung cancer cells, (3) induction of apoptosis and cell cycle arrest through activation of protein 53 (p53) expression and inhibition of key transcription factors, and (4) attenuation of the invasion/migration and metastasis of NSCLC cells through inhibition of the EMT [26].