Activation of nicotine-α7nAChR promotes cell invasion/proliferation in NSCLC cells, and EMT which is a key step in altering the malignant phenotype of cancer cell lines, resulting in suppression of E-cadherin and induction of MMPs, vimentin, fibronectin and N-cadherin expression [8,9,10]. The gene discussed is CDH2; the disease is non-small cell lung carcinoma.