STIM1 and asthma: The nicotine component of CSE contributes to asthma by promoting [Ca2+]I responses of human airway smooth muscle (hASM) cells to agonist and SOCE through upregulation expression of Orai1, CD38, stromal interaction molecule 1 (STIM1) and TRPC3 in hASM cells, which are the key molecular players for activation of sarcoplasmic reticulum Ca2+ release from ryanodine receptor channels [79].