BRCA1 and neoplasm: Based on the links between MET and cancer stem cells in multiple tumor types and the potential role of MET in treatment resistance, we also wanted to investigate the role of stem cell factors in the proposed synergistic effect of METi and PARPi in HGSC cell lines with mutations in either BRCA1 or BRCA2 and in their counterparts with restored BRCA1/2 function to emulate platinum-resistant disease.