In this context, Robinson et al. recently reported a stronger role for SOX2 compared to OCT4 or Nanog for tumor relapse potential following chemotherapy in ovarian cancer patients and that HGSC cell lines displayed greater chemoresistance and increased expression of SOX2, OCT4, and Nanog when grown in 3D conditions compared to 2D [39]. Here, POU5F1 is linked to neoplasm.