MAPK8 and colorectal carcinoma: Such treatments can alter the activities and protein expression of caspases, Bax, Bcl-2, PARP, JNK, MAPK, PI3K/AKT, integrin, WNT/β-catenin, STAT and PPARs and induce changes in the cell cycle, DNA damage and the CRC cellular functions of adhesion, migration and invasion, as well as the mitochondria and endoplasmic reticulum of these cells (Table 2).