Diets containing U. pinnatifida ethanol extracts, equivalent to 0.05% and 0.2% Fx, which has already demonstrated anti-obesity effects when administered through the diet in C57BL/6N mice, or another diet containing S. horneri powders (2% and 6%) reduced both the body and WAT weights in C57BL/6J mice fed a high-fat diet, with enhancement of the UCP-1 mRNA expression in WAT [118,119,120]. This evidence concerns the gene UCP1 and obesity due to melanocortin 4 receptor deficiency.