Ethanol extract from the brown algae Dictyopteris undulata augmented endoplasmic reticulum stress, abrogated mitochondrial membrane potential and induced apoptosis in human CRC SW480 cells through the enhancement of Bax; active caspase-3, caspase-9 and caspase-12; phospho-PERK; phospho-IRE1; cleaved ATF6; CAAT/enhancer-binding protein-homologous protein; and attenuation of Bcl-2 [79,80]. The gene discussed is BAX; the disease is colorectal carcinoma.