Herein, we tried to confirm the oncogenic role of G9a in HCC progression in vitro and in vivo using several HCC cell lines which were not reported to be problematic cell lines according to the information from Cellosaurus (https://web.expasy.org/cellosaurus/, accessed on 15 December 2020) and SciCrunch (https://scicrunch.org/resources, accessed on 15 December 2020). Here, EHMT2 is linked to hepatocellular carcinoma.