For example, the long non-coding (lnc)RNA, HOTAIR, was shown to suppress miR-122 expression in HCC cells via a histone methyltransferase, Enhancer of Zeste homolog 2 (EZH2)-induced upregulation of DNMTs, and further mediated DNA methylation of miR-122 [54]. This evidence concerns the gene EZH2 and hepatocellular carcinoma.