In addition, phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha (PIK3CA) and fibroblast growth factor 3 (FGFR3) mutations, both targetable, often occur in HPV+ but not in HPV− cancer, where p53 mutations dominate [28,40,49,67]. Here, PIK3CA is linked to cancer.