GSK-3β negotiates the nuclear factor-ҡ (NF-ҡB) pathway and so it plays a vital role in cell survival [40,41] specifically in colon cancer in which there is coactivation for both Wnt/β-catenin and NF-ҡB pathways through ubiquitin system dysregulation [42]. The gene discussed is GSK3B; the disease is malignant colon neoplasm.