In contrast, PGE2 also exists at high concentrations in the skin of patients with atopic dermatitis (lesional AD skin: mean 97.2 ng/gm, healthy skin: mean 27.1 ng/gm) [68] and PGE2-EP2 signaling enhances the protective effect against atopic dermatitis by suppressing TSLP production [70]. The gene discussed is TSLP; the disease is atopic eczema.