Analysis of a BC patient dataset from the Single Cell RNA-Seq Expression Atlas suggest that while many PI3K/mTOR-associated genes (e.g., PI3KCA, PI3KCB, MTOR, RSP6, and 4E-BP1) are ubiquitously expressed, PI3KCD (encoded for PI3Kδ) and PIK3CG (encoded for PI3Kγ) are preferentially expressed in PD-1+ lymphocytes in the primary and metastatic TNBC. This evidence concerns the gene RSPH6A and breast cancer.