Similarly, the repression of SIRT1 in mouse liver is sufficient to induce hepatic steatosis [187], an effect that might be mediated by the key regulators of glycolysis and lipolysis, peroxisome proliferator-activated receptor (Ppar)-γ and Pparα as Sirt1 deletion impairs their function [188,189]. The gene discussed is PPARA; the disease is fatty liver disease.