Similarly, the repression of SIRT1 in mouse liver is sufficient to induce hepatic steatosis [187], an effect that might be mediated by the key regulators of glycolysis and lipolysis, peroxisome proliferator-activated receptor (Ppar)-γ and Pparα as Sirt1 deletion impairs their function [188,189]. Here, SIRT1 is linked to fatty liver disease.