In A. thaliana, the single and double mutants of AtCAF1A and AtCAF1B were shown to decrease the expression of PATHOGENESIS-RELATED 1 (PR1) and PATHOGENESIS-RELATED 2 (PR2), and plants become more susceptible to Pseudomonas syringae pv tomato DC3000 (PST DC3000) infection; while plants overexpressing AtCAF1A showed high expression of PR1 and PR2 and exhibited enhanced resistance to the same pathogen [26]. The gene discussed is TMEM37; the disease is infection.