G6PD and pulmonary arterial hypertension: Joshi and colleagues studied mice of both sexes and found that genetic deletion of G6PD in mice prevented the development of hypoxic pulmonary hypertension and furthermore that shRNA mediated knockdown of G6PD or pharmacological inhibition of G6PD partially reversed established pulmonary hypertension in the hypoxia-CYP2C44−/− model of pulmonary arterial hypertension, a model in which female mice develop more severe pulmonary hypertension [78].