ACE2 and COVID-19: Based on in silico evidence, different flavonoids, likely tomentin A-E [287], chrysin [288], narcissin [289], cyaniding [290], and hesperetin [291], interacted with ACE2 and declined its neurological manifestation in COVID-19 [288,289,290,291], and also inhibited papain-like protease in COVID-19 [287].